Almost all of Florida's 24 milkweeds are native, and at least two of them are native only to Florida (endemic). Milkweeds are frequently encountered throughout the state, and the rest of North America. Different species are found in very wet habitats as well as in very dry ones.
This species, pinewoods milkweed, grows mostly in sandhills and scrubs (Wunderlin, 2003). Pineswoods milkweed is found in the southeast U.S. including Alabama, Florida, Georgia, Mississippi, North & South Carolina and (rarely) Louisiana (Kartesz, 1999). It blooms in the spring and summer.